A comprehensive database of high-throughput sequencing-based RNA secondary structure probing data (Structure Surfer)
نویسندگان
چکیده
منابع مشابه
RNAex: an RNA secondary structure prediction server enhanced by high-throughput structure-probing data
Several high-throughput technologies have been developed to probe RNA base pairs and loops at the transcriptome level in multiple species. However, to obtain the final RNA secondary structure, extensive effort and considerable expertise is required to statistically process the probing data and combine them with free energy models. Therefore, we developed an RNA secondary structure prediction se...
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Detection of reverse transcriptase termination sites is important in many different applications, such as structural probing of RNAs, rapid amplification of cDNA 50 ends (50 RACE), cap analysis of gene expression, and detection of RNA modifications and protein–RNA cross-links. The throughput of these methods can be increased by applying massive parallel sequencing technologies. Here, we describ...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2016
ISSN: 1471-2105
DOI: 10.1186/s12859-016-1071-0